Research
Because NDPH is a rare and heterogeneous condition, getting funding for research is nearly impossible. Most clinical trials that could potentially help NDPH sufferers are focused on migraine, tension headache, or chronic pain in general.
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Still, here is a list of studies that have shown potentially promising treatments for NDPH (*this page will hopefully be updated as new studies are published; if you have a study that you think should be included on this page, use the contact form below to submit it*)
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The Facebook group NDPH Alliance Resource Page also has a more up-to-date collection of NDPH research articles and WhatsApp group. To join, send a Facebook message to one of the admins:
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Update of New Daily Persistent Headache
Peng, KP., Wang, SJ. Update of New Daily Persistent Headache. Curr Pain Headache Rep 26, 79–84 (2022). https://doi.org/10.1007/s11916-022-01005-1
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New daily persistent headache after SARS-CoV-2 infection: a report of two cases
Dono, F., Consoli, S., Evangelista, G. et al. New daily persistent headache after SARS-CoV-2 infection: a report of two cases. Neurol Sci 42, 3965–3968 (2021). https://doi.org/10.1007/s10072-021-05444-3
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New Daily Persistent Headache and Potential New Therapeutic Agents.
Joshi, S.G., Mathew, P.G. & Markley, H.G. New Daily Persistent Headache and Potential New Therapeutic Agents. Curr Neurol Neurosci Rep 14, 425 (2014)
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"A Pain in the Head" Medical Mysteries, The Washington Post.
Boodman, S.G. (13 Nov. 2007). "A Pain in the Head." The Washington Post. https://www.washingtonpost.com/wp-dyn/content/article/2007/11/09/AR2007110902105.html
*Not research, but a newspaper article discussing how a headache above the bridge of a man's nose was attributed to swelling and compression of the ethmoid nerve in the sinuses, fixed by removing bony tissue and decompressing the nerve.
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Case report: Therapeutic response for new daily persistent headache by a tumor necrosis factor alpha antagonist, lithium
Bancalari, E. M., & Wicht, A. (2021). Case report: Therapeutic response for new daily persistent headache by a tumor necrosis factor alpha antagonist, lithium. Cephalalgia Reports, 4, 25158163211000316.
New daily persistent headache-like presentation triggered by sudden head-drop in a patient with myasthenia gravis
Upinder K. Dhand. Neurol Clin Pract Sep 2020, 10.1212/CPJ.0000000000000953; DOI: 10.1212/CPJ.0000000000000953
The Effect of Propofol on Chronic Headaches in Patients Undergoing Endoscopy
Giampetro D, Ruiz-Velasco V, Pruett A, Wicklund M, Knipe R. The Effect of Propofol on Chronic Headaches in Patients Undergoing Endoscopy. Pain Res Manag. 2018;2018:6018404. Published 2018 Jan 21. doi:10.1155/2018/6018404
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Resolution of new daily persistent headache with venlafaxine
Tariq Z, Board N, Eftimiades A, Ibrahim R. Resolution of new daily persistent headache by a tumor necrosis factor alpha antagonist, Venlafaxine. SAGE Open Med Case Rep. 2019;7:2050313X19847804. Published 2019 May 6. doi:10.1177/2050313X19847804
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Migraine Headache Treated with Famciclovir and Celecoxib: A Case Report
Napier BL, Morimoto M, Napier E. Migraine Headache Treated with Famciclovir and Celecoxib: A Case Report. Perm J. 2018;22:17-020. doi:10.7812/TPP/17-020
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RESPONSE OF REFRACTORY NEW DAILY PERSISTENT HEADACHE TO INTRAVENOUS LIDOCAINE TREATMENT IN A PEDIATRIC PATIENT
Akbar A (2017) Response of Refractory New Daily Persistent Headache to Intravenous Lidocaine Treatment in a Pediatric Patient. J Pain Relief 6:297. doi:10.4172/2167-0846.1000297
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Resolution of new daily persistent headache after osteopathic manipulative treatment
The Journal of the American Osteopathic Association, March 2016, Vol. 116, 182-185. doi:https://doi.org/10.7556/jaoa.2016.035
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Refining clinical features and therapeutic options of new daily persistent headache: a retrospective study of 63 patients in India
Prakash S, Saini S, Rana KR, Mahato P. Refining clinical features and therapeutic options of new daily persistent headache: a retrospective study of 63 patients in India. J Headache Pain. 2012;13(6):477-485. doi:10.1007/s10194-012-0461-6
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Memantine ameliorates migraine headache
Shanmugam S, Karunaikadal K, Varadarajan S, Krishnan M. Memantine Ameliorates Migraine Headache. Ann Indian Acad Neurol. 2019;22(3):286-290. doi:10.4103/aian.AIAN_294_18
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Tumour Necrosis Factor-Α, Interleukin-1 and Interleukin-6 Serum Levels and Its Correlation with Pain Severity in Chronic Tension-Type Headache Patients: Analysing Effect of Dexketoprofen Administration
Rambe AS, Sjahrir H, Machfoed MH. Tumour Necrosis Factor-Α, Interleukin-1 and Interleukin-6 Serum Levels and Its Correlation with Pain Severity in Chronic Tension-Type Headache Patients: Analysing Effect of Dexketoprofen Administration. Open Access Maced J Med Sci. 2017;5(1):54-57. doi:10.3889/oamjms.2017.024
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New Daily Persistent Headache and Potential New Therapeutic Agents
Joshi, S.G., Mathew, P.G. & Markley, H.G. New Daily Persistent Headache and Potential New Therapeutic Agents. Curr Neurol Neurosci Rep 14, 425 (2014). https://doi.org/10.1007/s11910-013-0425-5
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Mexiletine for refractory chronic daily headache: a report of nine cases
Marmura MJ, Passero FC Jr, Young WB. Mexiletine for refractory chronic daily headache: a report of nine cases. Headache. 2008 Nov-Dec;48(10):1506-10. doi: 10.1111/j.1526-4610.2008.01234.x. Epub 2008 Sep 12. PMID: 18793209.
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New daily persistent headache with a thunderclap headache onset and complete response to Nimodipine
Rozen and Beams: New daily persistent headache with a thunderclap headache onset and complete response to Nimodipine (A new distinct subtype of NDPH). The Journal of Headache and Pain 2013 14:100.
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Emerging evidence of occipital nerve compression in unremitting head and neck pain
Blake and Burstein The Journal of Headache and Pain (2019) 20:76 https://doi.org/10.1186/s10194-019-1023-y
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“Klingon headache” - a case report of mimic new daily persistent headache associated to primary essential cutisverticis gyrata
Di Stani F, Di Lorenzo L, Calistri V, Ruggeri AG, Araimo F, Brauneis S. "Klingon headache" - a case report of mimic new daily persistent headache associated to primary essential cutis verticis gyrata. Clin Ter. 2019;170(2):e77-e80. doi:10.7417/CT.2019.2112
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